生物活性
DHEA (Dehydroisoandrosterone) is an important endogenous steroid hormone; DHEA also has a variety of potential biological effects in its own right, binding to an array of nuclear and cell surface receptors and acting as a neurosteroid.
体外研究
体内研究
激酶实验
细胞实验
动物实验
不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数
例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。
参考文献
[1] Kimonides VG, et al. Proc Natl Acad Sci U S A, 1998, 95(4), 1852-1857.
[2] Biochem. Biophys. Res. Commun. 243, 771. Majewska, M.D., et al. 1990. Brain Res. 526, 143.
分子式 C19H28O2
分子量288.42
CAS号53-43-0
储存方式﹣20 ℃冷藏长期储存。冰袋运输
溶剂（常温）
DMSO50 mg/mL
Water<1 mg/mL
Ethanol50 mg/mL
体内溶解度
Clinical Trial Information ( data from http://clinicaltrials.gov )
NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated NCT02357472 Infertility Drug: dehydroepiandrosterone ShangHai Ji Ai Genetics & IVF Institute Phase 4 2014-12-01 2015-11-16 NCT02866253 Infertility Drug: DHEA ShangHai Ji Ai Genetics & IVF Institute Phase 4 2014-12-01 2016-08-13 NCT02150330 Dehydroepiandrosterone|DHEAS|Gene Expression of Cumulus Cells.|Ovarian Hyper-stimulation Protocol.|Artificial Reproduction Technology. Drug: Dehydroepiandrosterone (DHEAS) Taipei Veterans General Hospital, Taiwan|National YangMing University Phase 3 2013-01-01 2014-05-26 NCT00575341 Adrenal Insufficiency Drug: Dehydroepiandrosterone|Drug: placebo University Hospital Tuebingen Phase 3 2003-10-01 2007-12-17 NCT00289926 Quality of Life|Menopausal Syndrome|Libido Disorder Drug: dehydroepiandrosterone|Drug: placebo Monash University Phase 3 2006-02-01 2016-03-15 NCT02099916 Efficacy of DHEA|Pregnancy Rate|Diminished Ovarian Reserve|Changes in AMH Drug: gonadotropins plus DHEA|Drug: Gonadotropins University of Athens|Lito Maternity Hospital Phase 2|Phase 3 2014-10-01 2014-09-09 NCT00900900 Substance Withdrawal Syndrome Dietary Supplement: dehydroepiandrosterone (DHEA)|Dietary Supplement: pregnenolone|Drug: Placebo Jed E. Rose|Duke University Phase 2 2009-07-01 2012-09-14 NCT01915186 Female Infertility Due to Diminished Ovarian Reserve Dietary Supplement: Dihydroepiandrosterone (DHEA) The University of Hong Kong 2010-10-01 2013-12-19 NCT01256671 Vaginal Atrophy Drug: DHEA EndoCeutics Inc. Phase 3 2010-12-01 2016-02-19 NCT00429806 Vaginal Atrophy Drug: DHEA|Drug: Placebo Centre Hospitalier Universitaire de Qu茅bec, CHU de Qu茅bec Phase 1 2006-11-01 2016-03-19 NCT00581087 Chronic Obstructive Pulmonary Disease|Hypertension, Pulmonary Drug: DHEA treatment|Drug: Placebo University Hospital, Bordeaux Phase 3 2007-01-01 2015-01-13 NCT00650754 Primary Ovarian Insufficiency|Unexplained Infertility Dietary Supplement: Dehydroepiandrosterone|Other: Placebo Center for Human Reproduction Phase 2|Phase 3 2008-03-01 2015-09-28 NCT02561793 Subfertility Drug: DHEA|Drug: Placebo Cairo University Phase 3 2015-10-01 2016-07-03 NCT02432248 Subfertility Drug: Dehydroepiandrosterone|Other: placebo(medical starch) The Affiliated Hospital of Inner Mongolia Medical University|First Affiliated Hospital, Sun Yat-Sen University|Renmin Hospital of Wuhan University 2015-02-01 2015-04-28 NCT00948857 Premature Ovarian Failure Dietary Supplement: Dehydroepiandrosterone|Dietary Supplement: Placebo David H. Barad|Center for Human Reproduction Phase 2|Phase 3 2009-06-01 2012-09-04 NCT01452373 Vasomotor Symptoms|Hot Flushes Drug: Placebo|Drug: DHEA and Acolbifene EndoCeutics Inc. Phase 3 2011-10-01 2013-12-10 NCT02683148 Synovial Sarcoma|Sarcoma, Synovial Drug: DHEA|Other: FACT-67 validated survey Washington University School of Medicine Phase 1|Phase 2 2016-09-13 2017-02-14 NCT01256684 Vaginal Atrophy Drug: Placebo|Drug: DHEA|Drug: DHEA EndoCeutics Inc. Phase 3 2010-12-01 2016-02-19 NCT01861847 PTSD Drug: 7-Keto Dehydroepiandrosterone|Drug: Placebo Humanetics Corporation Phase 2 2013-02-01 2015-10-07 NCT00419913 Infertility|Decreased Ovarian Reserve Dietary Supplement: Dehydroepiandrosterone Center for Human Reproduction|Foundation for Reproductive Medicine Phase 2|Phase 3 2007-01-01 2008-03-31
注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。
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